▾ G11 Media Network: | ChannelCity | ImpresaCity | SecurityOpenLab | GreenCity | Italian Channel Awards | Italian Project Awards | ...
InnovationOpenLab

Advanced Infliximab Model Now Available from DoseMe

DoseMe, a leading provider of model-informed precision dosing, today announced the availability of its Infliximab model. Infliximab (IFX) is a purified, recombinant DNA-derived chimeric IgG monoclonal...

Business Wire

JUPITER, Fla.: DoseMe, a leading provider of model-informed precision dosing, today announced the availability of its Infliximab model.

Infliximab (IFX) is a purified, recombinant DNA-derived chimeric IgG monoclonal antibody protein that contains both murine and human components that inhibit tumor necrosis factor-alpha(TNFα). Anti-TNF agents, including infliximab, are the first biological agents effective in inducing and maintaining remission in inflammatory bowel disease (IBD) and have improved outcomes of common chronic immune-mediated inflammatory diseases in adults and children.

“Clinical efficacy of infliximab is critically dependent on addressing the influences of individual variability during active disease on drug clearance, which puts patients at higher risk of inadequate exposure leading to development of immunogenicity potentially resulting in treatment failure,” states Sharmeen Roy, PharmD, BCPS, Chief Strategy & Science Officer, DoseMe. “Biological agents are expensive; by integrating therapeutic drug monitoring with model-informed precision dosing, we can adjust dosing based on measurable pharmacological markers and immunogenic profiles, thereby enhancing the potential for improving patient outcomes.”

The models available for adults and pediatric patients consider covariates impacting infliximab PK for patients with various inflammatory disorders.

DoseMe continues to innovate by combining innovative technology with science, leveraging clinically validated PK/PD models, patient characteristics, drug concentrations, and genotypes to accurately individualize a dose in seconds. "We continue to enhance our models, and this model may predict infliximab concentration in patients with anti-drug antibodies,” added Roy. “Both the learning set and validation set of this model had a large diversity in an indication of the patients, thus making this model especially equipped to dose infliximab for many indications.”

For more information and an overview of all models currently available, visit https://doseme-rx.com/why-dosemerx/drug-packages

Additional Resources

Connect with DoseMe on LinkedIn
Follow DoseMe on Twitter
Bookmark the DoseMe Blog
Visit the DoseMe Newsroom
Contact DoseMe

About DoseMe

DoseMe combines smart technology with science, leveraging clinically validated PK/PD models, patient characteristics, drug concentrations, and genotypes to accurately individualize a dose in seconds. The platform is HIPAA, ISO & FDA compliant and the only Bayesian dosing platform to be HITRUST CSF certified. For more information on successful applications of its products, DoseMeRx and DoseMe Analytics, visit https://doseme-rx.com/success-stories

Fonte: Business Wire

If you liked this article and want to stay up to date with news from InnovationOpenLab.com subscribe to ours Free newsletter.

Related news

Last News

Bending Spoons acquires StreamYard

The Italian tech company has entered into an agreement to buy the US based live-streaming and video-recording business

HR startup's market is on fire, ask to Factorial

Factorial secures $80M of Go-To-Market investment from General Catalyst to accelerate growth.

Awentia brings Italian Deep Tech to South America

From Imola, Awentia Agritech will take its Smart Agriculture technologies to Argentinian companies Ava Fruit, Doña Paula and Bodega A16

San Francisco's INNOVIT among Invitalia Startup System partners

New overseas opportunities for startups funded by Invitalia

Most read

Awentia brings Italian Deep Tech to South America

From Imola, Awentia Agritech will take its Smart Agriculture technologies to Argentinian companies Ava Fruit, Doña Paula and Bodega A16

Bending Spoons acquires StreamYard

The Italian tech company has entered into an agreement to buy the US based live-streaming and video-recording business

San Francisco's INNOVIT among Invitalia Startup System partners

New overseas opportunities for startups funded by Invitalia

HR startup's market is on fire, ask to Factorial

Factorial secures $80M of Go-To-Market investment from General Catalyst to accelerate growth.

Newsletter signup

Join our mailing list to get weekly updates delivered to your inbox.

Sign me up!