▾ G11 Media Network: | ChannelCity | ImpresaCity | SecurityOpenLab | GreenCity | Italian Channel Awards | Italian Project Awards | ...
InnovationOpenLab

Crown Bioscience Introduces OrganoidXplore: Revolutionizing Cancer Research with Rapid Large-scale Organoid Drug Screening

Crown Bioscience, a global contract research organization (CRO) and JSR Life Sciences company, today announced the launch of its ground-breaking service offering, OrganoidXploreTM. This large-scale or...

Business Wire

SAN DIEGO: Crown Bioscience, a global contract research organization (CRO) and JSR Life Sciences company, today announced the launch of its ground-breaking service offering, OrganoidXploreTM. This large-scale organoid panel screening platform promises robust, reproducible, and clinically relevant output at record speed, accelerating preclinical oncology drug discovery by empowering researchers and reshaping the landscape of cancer treatment development.

Screening of a large panel of patient-derived organoids is enabled using Crown Bioscience’s unique assay-ready (AR) organoid technology. Recent posters presented at the AACR annual meeting and ANE international conference 2023 demonstrate the performance of assay-ready organoids against freshly prepared organoids – the traditional methodology. The study demonstrated the utility of OrganoidXplore and revealed:

  • Highly Robust Performance: Both the assay-ready and original methods consistently performed with high accuracy across multiple assays.
  • Accelerated Timelines and Reduced Costs: OrganoidXplore slashed project timelines by two-thirds, when compared to standard methods.
  • Reliable and Reproducible Drug Response Comparisons: Both methods showed analogous results in cell viability (CTG) and high content imaging (HCI) assays when tested with standard drugs such as paclitaxel, carboplatin, and cisplatin.

OrganoidXplore transcends traditional 2D cell culture systems in terms of patient relevance, heralding a significant leap in preclinical drug screening. By accurately replicating the genomic, morphological, and pathophysiological attributes of original tumors, researchers are now equipped to screen against an extensive range of predictive models. Results can be obtained within an expedited timeframe of just six weeks, magnifying research speed three-fold and anchoring its promise on the robustness and reproducibility of its advanced assay-ready technology.

Researchers can choose between a comprehensive Full Panel or a specialized KRAS Panel to meet their specific goals. The Full Panel currently comprises 50 organoid models covering seven cancer indications, which are also available as companion Patient-Derived Xenografts (PDX). The KRAS Panel specifically targets four cancer indications, with 25 models covering a broad range of KRAS mutations. These models are also available as PDX, allowing for a seamless transition to follow-on studies.

In combination with comprehensive next-generation sequencing (NGS) characterization, including whole exome sequencing (WES) and RNA sequencing (RNAseq), OrganoidXplore enables expedited biomarker identification, highly relevant mechanism of action studies, selection of indications and/or models, investigation of drug repurposing, and improved patient stratification.

Leo Price, PhD, Senior Vice President, In Vitro and Head of Crown Bioscience Netherlands, said: “OrganoidXplore addresses the exacting demands of pioneering research initiatives by offering a diverse selection of models that cover a wide spectrum of genetic backgrounds and mutations. Thanks to the implementation of innovative organoid cryopreservation technology automation and assay automation, OrganoidXplore’s precision, speed, and reproducibility are unrivaled.”

Crown Bioscience remains steadfast in its commitment to driving innovations in oncology research, evidenced by the introduction of OrganoidXplore, designed with the mission to accelerate drug discovery.

###

About Crown Bioscience

Crown Bioscience, a JSR Life Sciences company, is a global CRO that provides preclinical and translational platforms to help our customers advance their research and development in oncology and immuno-oncology. We are the exclusive preclinical CRO to offer tumor organoid services with the well-established Hubrecht Organoid Technology, offering over 600 organoid models spanning 22 cancer indications. In addition, we have developed the largest commercially available PDX collection in the world. We focus on helping our customers develop novel therapies to maximize the chances that patients receive the right treatment at the right time. Founded in 2006, Crown Bioscience has 13 facilities across the United States, Europe, and Asia.

For more information or to get in touch, please visit www.crownbio.com

Contacts

Media Inquiries:
Crown Bioscience
Sarah Martin-Tyrrell
pr@crownbio.com

Fonte: Business Wire

If you liked this article and want to stay up to date with news from InnovationOpenLab.com subscribe to ours Free newsletter.

Related news

Last News

Displaid selected by Bravo Innovation Hub

Displaid is a monitoring-as-a-Service startup that improves the management of infrastructure networks by identifying the types of damage in advance.

Lottomatica Group buys SKS365

Through the deal, Lottomatica would become the outright largest omnichannel gambling group in the Italian market.

Italian Apio for the cocoa supply chain in Africa

Apio revealed his blockchain platform at the Eurochocolate fair in Perugia (Italy).

Siav Group of Italy for the first time at Gitex in Dubai

The Enterprise Content Management company presents its international strategy along with the new Siav Connect platform and Checker app

Most read

VPN Black Friday & Cyber Monday Deals 2023: Top Surfshark, ExpressVPN,…

Compare the top VPN deals for Black Friday and Cyber Monday 2023, including all the best Surfshark, NordVPN, ExpressVPN, CyberGhost VPN, Ivacy VPN, and…

HARMAN Acquires Roon, a popular Multi-Device, Multi-Room Audio Technology…

HARMAN, a wholly-owned subsidiary of Samsung Electronics Co., Ltd. focused on connected technologies for automotive, consumer, and enterprise markets,…

Salesforce and AWS Expand Partnership for Customers to More Easily Build…

At AWS re:Invent, Amazon Web Services (AWS), an Amazon.com, Inc. company (NASDAQ: AMZN), and Salesforce, the #1 AI CRM (NYSE: CRM), today announced a…

The 5th World Science and Technology Development Forum Opens in Shenzhen

On the November 24, the 5th World Science and Technology Development Forum (WSTDF) opened in Shenzhen, Guangdong. Chairman of the China Association for…

Newsletter signup

Join our mailing list to get weekly updates delivered to your inbox.

Sign me up!